molecularmechanism相关论文
肺癌是癌症相关死亡的主要原因，其发病率和死亡率均位居前列，严重影响患者的生存时间和生命质量。开发新的肿瘤细胞作用靶点，扩大肺癌......
Background and Aims: Protein phosphatase 2A (PP2A) is associated with many cancers. This study aimed to clarify whether ......
A Network Pharmacology Study to Uncover the Multiple Molecular Mechanism of the Chinese Patent Medic
Since the outbreak of the novel corona virus disease 2019 (COVID-19) at the end of 2019,specific antiviral drugs have be......
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Priapism is defined as abnormal prolonged penile erection occurring beyond or unrelated to sexual interest. The disorder......
The molecular mechanism of vascular endothelial growth factor A(VEGFA)gene for hypoxic adaptation in
Vascular endothelial growth factor A (VEGFA) can induce endothelial cell proliferation,promote cell migration,and inhibi......
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Effect of Atmospheric-Pressure Plasma-jet on Living Cancer Cell and Its Underlying Molecular Mechani
The plasma jet has been proposed as a novel therapeutics for anticancer treatment.Recently,we and others have reported t......
Over the past 50 years,the control of insects with fungal pathogens has been a very active of research and has resulted ......
Development of angiotensin I-converting enzyme(ACE,EC 3.4.15.1)inhibitory peptides from food protein is under extensive ......
Transcriptome Sequencing Identified Genes and Gene Ontologies Associated with Early Freezing Toleran
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Kaempferol inhibits cell proliferation and induces apoptosis in human pancreatic cancer via ROS-depe
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GIPC1 Promotes the proliferation,migration and invasion of hepatocellular carcinoma cells and its mo
Objective GIPC1 is an intracellular scaffold protein,which plays an important role in the transport and regulation of ce......
Application of Computational Systems Toxicology in Understanding of Drug-induced Hepatotoxicity Mech
Drug-induced hepatotoxicity is a leading cause of acute liver failure worldwide and one of the most frequent reasons for......
Traditional Chinese Medicine (TCM) is characterized with complexity and holism in both diagnostic and therapeutic princi......
Genes and gene regulation associated with pyrethroid resistance in the malaria vector Anopheles sine
Pyrethroids of insecticide are still the most important weapon for the control of disease vectors, and it is also often ......
Molecular basis for toxin resistance of Mesobuthus martensii voltage-gated potassium channel: insigh
It remains unclear why scorpions are immune to own venoms containing various neurotoxins specific for the mammalian or i......
Jaridonin, a novel anticancer drug, induced human gastric cancer cell line MGC-803 autophagy and Its
Aim: Jaridonir, a novel ent-kaurane diterpenoid compound from Isodon Rubescens in our laboratory.We designed the current......
Independent lipid-lowering effects of statins in cerebral ischemia and the potential molecular mecha
Cerebral ischemia (stroke) is the second leading cause of death worldwide among numerous cardio-cerebrovascular diseases......
Aqueous extract of Trametes robiniophila murr(Huaier)has been applied for cancer complementary therapy in recent decades......
Structural Characterization of Staphylococcus aureus AldH,an Aldehyde Dehydrogenase in Staphyloxanth
Staphylococcus aureus(S.aureus)is a major human pathogen causing hospital and community acquired infection....
Study on the mechanism of Guizhi Fuling pill in the treatment of ovarian cancer based on network pha
Objective: To explore the main active components and mechanism of Guizhi Fuling pill in the treatment of ovarian cancer ......
骨愈合是一个复杂的、被精细调控的过程，涉及到炎性反应、血管新生、间充质干细胞分化、血管内皮细胞及骨相关细胞增殖、细胞自噬等......
胰腺癌具有高度的侵袭性和转移性，发生发展过程中涉及的分子机制十分复杂。近年来，越来越多的胰腺癌相关长链非编码RNA(lncRNA)被发......
Photorhabdus(Enterobacteriaceae)bacteria are pathogenic to insects and mutualistic with entomopathogenci Heterorhabd......
Functional characterization and molecular mechanism of a Glycine soja receptor like kinase GsCBRLK u
Due to its great salt-alkali resistance, Glycine soja is considered to be an ideal material for studying salt-alkali mol......
Protease-producing bacteria are considered to be key players for the degradation of organic nitrogen in marine environme......
It is increasingly accepted that enzyme promiscuity is not a rare phenomenon; rather,it appears to be widespread and......
Association between changes in reproductive activity and D-glucose in the tephritid fruit fly, Bactr
Reproduction is an important life process in insects; however,few studies have attempted to demonstrate the associat......
Calcium-activated chloride channels (CaCCs) play important roles in many physiological processes which is dependent ......
Anopheles sinensis genome sequence provides insights into the molecular mechanism of pyrethroid resi
Pyrethroids of insecticide are still the most important weapon for the control of disease vectors,and it is also oft......
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Organisms have variable gcnome sizes and contain different numbers of genes. This difference demonstrates that new gene ......
精子趋化作用具有重要的生理功能，体现在这种趋化过程促使大量的精子到达受精部位，从而实现精子与卵子的相遇、顶体反应的发生及精卵......
Raspberry ketone attenuates high-fat diet-induced obesity by improving metabolic homeostasis in rats
Objective: To investigate the molecular mechanisms of the anti-obese effect of raspberry ketone against high-fat diet fe......
Gibberella ear rot (GER) caused by Fusarium graminearum (teleomorph Gibberella zeae) is a common maize disease that not ......
BACKGROUND: To summarize the metabolic pathway of 1-methyl-4-phenyl-1,2,3,6-tetradropyridine (MPTP)and its mechanism in ......
Raf激酶抑制蛋白(RKIP)是从牛脑中纯化的一种小胞质蛋白,属于磷脂酰乙醇胺结合蛋白家族,具有多重分子与细胞功能.RKIP调节促分裂原......
长链非编码RNA(LncRNA) H19是最早发现的长链非编码RNA分子之一,H19在机体生长发育、肿瘤发生、发展等多种生物学功能方面发挥巨大......
转化生长因子-β(TGF-β)对角膜基质瘢痕形成具有极其重要的生物学效应,而且是导致细胞外基质(ECM)异常沉积及胶原纤维结构异常的......
地方性砷中毒是我国政府高度重视的地方病，但受砷致病机制不明、缺乏癌变早期诊断指标以及无特效治疗药物等限制，地方性砷中毒尚未得......
先天性心脏病(CHD)是目前最常见的出生缺陷,其病因复杂,涉及遗传因素和环境因素的共同作用.其中,母亲孕前糖尿病与胎儿CHD的发生具......
随着对癫癎研究的不断深入，癫癎发作的时相性越来越受到关注。癫癎发作存在生物节律，同一类型的癫癎在不同时间段、不同状态（睡眠/觉......
心房颤动是临床常见的持续性心律失常,发病率随着年龄增加而逐渐升高,致死和致残率高.目前对心房颤动的治疗仍然缺乏有效的措施,其......
Kv4.3通道蛋白作为瞬时外向钾电流的核心功能结构,在心肌细胞早期复极化中发挥重要作用.Kv4.3通道蛋白下调致使动作电位时程延长,......
心房颤动是临床最常见的心律失常之一,糖尿病促进心房颤动的发生近年引起重视;但糖尿病导致心房颤动的分子机制仍不清楚.对于在心......
目的观察咪唑克生（IDA）对内毒素脂多糖（LPS）攻击小鼠体内以及体外活化巨噬细胞的抗炎效应，探讨其可能的分子机制。方法体内实验：将30只成......
Interaction between hepatitis C virus core protein and translin protein- a possible molecular mechan
AIM: To investigate the interaction between hepatitis C viruscore protein and translin protein and its role in thepathog......
Involvement of extracellular signal-regulated kinase/mitogen activated protein kinase pathway in mul
AIM: To investigate the molecular mechanism of the influence of HBx protein on multidrug resistance associated genes:mul......
The molecular mechanism of how hepatocytes maintain cholesterol homeostasis has become much more transparent with the di......
